Guglielmo Vicario is an Italian professional footballer who plays as a goalkeeper. Vicario made his Serie C debut for Venezia on 5 March 2017 in a game against Teramo. On 17 July 2019, he signed a five-year contract with Cagliari. On 25 July 2019, he joined Perugia on a season-long loan, before he joined Empoli. On 17 September 2022, Vicario received his first Italy national football team callup, as manager Roberto Mancini named him to be part of the squad for the UEFA Nations League games against England and Hungary.